FIDELITY OF HUMAN OVARIAN CANCER PATIENT-DERIVED XENOGRAFTS IN A PARTIALLY HUMANIZED MOUSE MODEL FOR PRECLINICAL TESTING OF IMMUNOTHERAPIES

Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies

Background Immune checkpoint blockers (ICBs) have been approved by the Food and Drug Administration to be used alone in front-line therapies or in combination with other regimens for certain advanced cancers.Since ICB only works in a subset of patients and has limited efficacy in treating ovarian cancer (OVC), developing preclinical models that hel

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